Breaking left-right symmetry
Most animals exhibit overall bilateral symmetry but many also demonstrate consistent left-right (L-R) asymmetries. The position and patterning of the internal organs of vertebrates provide prime examples of such asymmetries. Moreover, the L-R axis is consistently polarized: organs are patterned with invariant handedness rather than
motile cilia and left-right asymmetry
polycystin proteins and flow signal transduction
Little is known about how asymmetric fluid flow is sensed by cells to give rise to downstream asymmetries in gene expression.