ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling

A Harris, P Siggers, S Corrochano, N Warr, D Sagar, DT Grimes, M Suzuki, RD Burdine, F Cong, B-K Koo, H Clevers, I Stevant, S Nef, S Wells, R Brauner, BB Rhouma, N Belguith, C Eozenou, J Bignon-Topalovic, A Bashamboo, K McElreavey#, Greenfield A#

PNAS 115(21):5474-9 (2018)

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Left-right asymmetry: breaking symmetry to asymmetric morphogenesis

DT Grimes#, RD Burdine#

Trends Genet. 33(9):616-28 (2017)

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Modeling syndromic congenital heart defects in zebrafish

MG Grant*, VL Patterson*, DT Grimes, RD Burdine

Curr. Top. Dev Biol. 124:1-40 (2017)

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Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning

RD Burdine, DT Grimes

Phil. Trans. Royal Soc. B 371(1710):pii:2015402 (2016)

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Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature

DT Grimes*, CW Boswell*, NFC Morante*, RM Henkelman, RD Burdine, B Ciruna

Science 352(6291):1341-44 (2016)

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NIH Director's Blog | Wired

Genetic analysis reveals a hierarchy of interactions between Polycystin-encoding genes and genes controlling cilia function during left-right determination

DT Grimes, JL Keynton, MT Buenavista, X Jin, Patel SH, K Shinohara, J Vibert, DJ Williams, H Hamada, R Hussain, SM Nauli, DP Norris

Plos Genetics 12(6):e1006070 (2016)

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c21orf59/kurly controls both cilia motility and polarization

K Jaffe*, DT Grimes*, J Schottenfeld-Roames*, ME Werner, T Ku, SK Kim, JL Pelliccia, NFC Morante, BJ Mitchell#, RD Burdine#

Cell Reports 14(8):1841-9 (2016)

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Princeton Research

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis

P Goggolidou*, JL Stevens*, F Agueci, JL Keynton, G Wheway, DT Grimes, SH Patel, H Hilton, SK Morthorst, A DiPaolo, DJ Williams, J Sanderson, S Khoronenkova, N Powles-Glover, A Ermakov, C Esapa, R Romero, GL Dianov, J Briscoe, C Johnson, LB Pedersen, DP Norris

Development 141(20):2966-77 (2014)

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Cilia discern left from right

DP Norris, DT Grimes

Science 338(6104):206-7 (2012)

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Mouse models of ciliopathies: the state of the art

DP Norris, DT Grimes

Dis. Models Mech. 5(3):299-312 (2012)

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Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

S Field*, KL Riley*, DT Grimes*, H Hilton, M Simon, N Powles-Glover, P Siggers, D Bogani, A Greenfield, DP Norris

Development 138(6):1131-42 (2011)

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Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway

VL Patterson, C Damrau, A Paudyal, B Reeve, DT Grimes, ME Stewart, DJ Williams, P Siggers, A Greenfield, JN Murdoch

Hum. Mol. Genet. 18(10):1719-39 (2009)

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